Paraoxonase-1 (PON1) s an hgh densty lpoproten (HDL)-assocated enzyme wth antoxdant and antatherogenc functons, protectng lpoprotens aganst oxdatve modficaton  It also catalyzes the hydrolyss of organophosphates such as paraoxon and aromatc carboxylc acd esters of fatty acds. It has been shown that serum paraoxonase actvty decrease n dabetes melltus, coronary artery dsease, hypercholesterolaema, ron deficency annema, heepatts, crrhoss, prostate cancer, tuberculoss and nfla mattons.